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KMID : 0380319870400000081
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Journal of Korean Research Institute for Better Living
1987 Volume.40 No. 0 p.81 ~ p.92
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The Effects of Hydroxyurea on Mitomycin C Induced Chromosome·Aberrations
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Abstract
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The present study was undertaken in an attempt to examine the potentiation by hydroxyurea in G_2 of mitomycin C-induced chromosomal aberrations in human leukocytes, comparing mitotic obtained were as follows:
1. Mitotic index when treated with mitomycin C and hydroxyurea decreased significantly, compared with single treatment of mitomycin C or hydroxyurea.
2. Frequencies of chromosomal aberrations increased significantly when treated with mitomycin C and hydroxyurea, compared with single treatment of mitomycin C or hydroxyurea.
3. Chromosome gaps among types of chromosomal aberrations were induced most frequently when treated with mitomycin C and/or hydroxyurea and chromosome breaks showed dominantly when treated with mitomycin C and hydroxyurea.
4. Chromosomal aberrations were induced mostly in the A, B, C and D chromosome group. Chromosome gaps were induced with significant difference among the A, B, C and D group when treated with mitomycin C and hydroxyurea, and among the A, B and D group when treated with mitomycin C.
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